I'm sure this horrid luck with drops plagues some of you as well, so this is how I farmed my Mists Essence solo:
I bought a full set of green Explorer armor, a full set of green Opal jewelry, 3 Major Pirate Runes, 3 Major Traveler Runes, a yellow Axe with magic find, a Major Sigil of Luck, and some peach tarts. These are not the best magic find items, but they offer a LOT of magic find for around 2 gold total.
I then went in and out of level 9 fractals until I found one that contained easy to kill mobs that respawned quickly and dropped loot. Surprisingly, many of the mobs that respwn indefinitely do NOT have a chance to drop any loot.
You can tell a mob has a chance to drop loot because your Sigil of Luck counter will only increment if the mob you kill has a chance to drop loot.
I finally settled on the swamp fractal. The Jungle Spiders, Mosquitos, Fireflys, and Slamoths all made the Sigil of Luck counter increment, so they all have a chance to drop loot. They die quickly. They respawn quickly. I ended up making a circuit killing the 3 Mosquitos near the pillars, then the 3 Jungle Spiders near the spider egg wisp, then the 3 Fireflies just beyond the annoying wall in front of the pillars. I skipped the Slamoths because they were more out of the way and the other mobs respawned fast enough.
After about 45 minutes of nonstop killing I finally got my first Vial of Mists Essence.
I know this may seem pointless to most of you that have gotten many of these vials to drop, but I was one of those unlucky few that has never seen one in dozens of fractal runs. This is a way to farm by yourself until you have some agony resist to help you get past level 10.
Edited by Enscheff, 19 December 2012 - 05:53 PM.