Personally I could find a game like that interesting. But only if the concept would add actual depth to the game. What you have for example in Dark Souls, is just a gimmick. The game would be almost exactly the same without any death penalty. You'd just play less carefully and try more "stupid" things. Eve online however, could never work without it's risk vs. reward structure.
In any case, I would not want this kind of stuff to be part of Guild Wars. I always thought Guild Wars as a game that is all about playing some part of the game, and not about analysing if that part of the game is worth doing.