Patience I have. Knowledge, in this context, not so much. How did you know that snowflakes would sell for a lot later on? Or flame dye? How did you determine that you could craft a particular item profitably? How did you determine that there was adequate demand for that item that it would sell in a reasonable time once you crafted it?
I'm aware that the solution is "research" but that's just a grind of a different kind. Sometimes one gets lucky and stumbles on a profitable secret. More often than not, I've found, uncovering that secret means lots of reading and calculating before you discover a hidden gem.