I agree with Dempsey911, if you're not a fan of Glass Cannon, just go fully Knights, and transition yourself slowly towards Zerker, so use Ruby Orbs in armor slots, and use Exquisite Ruby Jewels in your accessories (or if you're getting Ascended accessories, get those as Zerker). When you want to transition to more damage, the first things to go should be Accessory slots.
In addition to this, further what Dempsey is saying about Vitality, yes it really isn't much good to you, and this is because you're a warrior. Vitality can be good for soaking conditions, sure, but when you're in even a marginally balanced team, someone is going to be throwing around some kind of condition removal. Getting hit for several k is usually what you worry about, few enemies provide enough condition damage to truly ruin you (I can think of Risen Defilers in Arah with that brutal poison).
However, Vitality can pay dividends for those classes that have very low health, like Thieves for example. A bit of vitality for those classes can mean the difference between being one-shot, and not being one-shot. However since Warrior's typically don't get one-shot by anything (excluding mob mechanics *specifically* designed to one-shot), you don't have to worry about vitality here.
As Dempsey says, Toughness will take you a lot further, and Knights gives you a good platform for DPS. In addition to this, having high Toughness opens up a great yield from other Nourishment buffs such as Sharpening Stones and Maintenance oils, both of which provide a higher proportion of their buff from Toughness (6% at max tier) than from Vitality (4% at max tier).
In general, the over-arching argument against tanking yourself out too much is that it can spark the wrong kind of attitude. If dodging is not your strong point, that's ok, but the answer to that is to get better at anticipating enemy attacks and follow all the little tricks to avoiding damage. Things like how you should always stand behind your enemy (so you avoid Cleave), also you should try and put "something" between you and the enemy, so that you don't get hit (i.e. a ranger pet). A lot of people don't realise how another body can block damage for you. If you just stand there, no combination of Toughness and Vitality will save you unfortunately. Footwork will always eclipse tankiness, in fact even using the word "tank" or any variation of it is inherently false, since it isn't a mandatory playstyle for any team.
Sithicus DiasMember Since 13 Sep 2012
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