Gear: Full Berserker. Self-explanatory. Put Strength sigils on everything, Accuracy if offhand.
Runes: 2x Superior Monk, 2x Superior Water, 2x Major Sanctuary. This gives you +40% boon duration, probably the best buff you will get from any rune combination in general.
First of all thanks--been looking to dust my Guardian off but...
What are these runes you speak of? Monk? Sanctuary is a sigil and goes not on armor but weapons no?
Everything else seems straight-forward